Triethyl orthoacetate → HCID 13290549, compound

HRID 1903881Notes

Reaction equation

HRID 1903881 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:4][C:3]=1[NH:12][C:13]1[CH:27]=[CH:26][C:16]([O:17][CH:18]([CH2:23][O:24][CH3:25])[C:19]([O:21][CH3:22])=[O:20])=[CH:15][CH:14]=1.[C:28](OCC)(OCC)(OCC)[CH3:29]>>[CH3:28][C:29]1[N:12]([C:13]2[CH:14]=[CH:15][C:16]([O:17][CH:18]([CH2:23][O:24][CH3:25])[C:19]([O:21][CH3:22])=[O:20])=[CH:26][CH:27]=2)[C:3]2[CH:4]=[CH:5][C:6]([C:8]([F:11])([F:10])[F:9])=[CH:7][C:2]=2[N:1]=1

Participants

3

Reactant 2

HCID 66221Triethyl orthoacetateHCID 20456650HCID 20456650, compound

Product 1

HCID 13290549HCID 13290549, compound

Procedure

A solution of 7 g of 10C in 25 ml of triethyl orthoacetate was refluxed for 4 hours. The resulting mixture was concentrated in a rotary evaporator and chromatographed over silica gel to give 10, as a viscous oil.

Workup

  1. concentrationThe resulting mixture was concentrated in a rotary evaporator
  2. customchromatographed over silica gel

Sources & evidence

ORD record
ord-c7b9bb2ee66341a6803dcf22b725194d
Source dataset
uspto-grants-1984_03
Patent number
US04439226

Reaction notes

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