HCID 53811802, compound → HCID 13290551, compound

HRID 1903883Notes

Reaction equation

HRID 1903883 reaction equation
[N+:1]([C:4]1[CH:9]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:7]=[CH:6][C:5]=1[NH:14][C:15]1[CH:28]=[CH:27][C:18]([O:19][CH:20]([CH3:26])[CH:21]=[CH:22][C:23]([OH:25])=[O:24])=[CH:17][CH:16]=1)([O-])=O.[H][H]>O1CCCC1>[NH2:1][C:4]1[CH:9]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:7]=[CH:6][C:5]=1[NH:14][C:15]1[CH:16]=[CH:17][C:18]([O:19][CH:20]([CH3:26])[CH2:21][CH2:22][C:23]([OH:25])=[O:24])=[CH:27][CH:28]=1

Participants

4

Reactant 2

HCID 53811802HCID 53811802, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 13290551HCID 13290551, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

12D, in solution in tetrahydrofuran, was placed on a Parr shaker and treated with hydrogen (40 psi hydrogen pressure, Parr shaker, 10% palladium-on-charcoal catalyst) to give 4-(4-(2-amino-4-(trifluoromethyl)phenylamino)phenoxy)pentanoic acid (12E), as an oil.

Sources & evidence

ORD record
ord-965885ff0b3f41738b4115394d7e1e70
Source dataset
uspto-grants-1984_03
Patent number
US04439226

Reaction notes

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