Sodium Hydroxide → HCID 13290548, compound

HRID 1903884Notes

Reaction equation

HRID 1903884 reaction equation
[CH3:1][C:2]1[N:6]([C:7]2[CH:22]=[CH:21][C:10]([O:11][CH:12]([CH3:20])[CH2:13][CH2:14][C:15]([O:17]CC)=[O:16])=[CH:9][CH:8]=2)[C:5]2[CH:23]=[CH:24][C:25]([C:27]([F:30])([F:29])[F:28])=[CH:26][C:4]=2[N:3]=1.[OH-].[Na+]>C(O)C>[CH3:1][C:2]1[N:6]([C:7]2[CH:22]=[CH:21][C:10]([O:11][CH:12]([CH3:20])[CH2:13][CH2:14][C:15]([OH:17])=[O:16])=[CH:9][CH:8]=2)[C:5]2[CH:23]=[CH:24][C:25]([C:27]([F:28])([F:29])[F:30])=[CH:26][C:4]=2[N:3]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 13290552HCID 13290552, compound

Product 1

HCID 13290548HCID 13290548, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 2.4 g of 12 and 0.25 g of sodium hydroxide in 50 ml of aqueous ethanol was refluxed for one hour, and extracted with ether. The extract was dried and concentrated. The residue was crystallized from ether-hexane to give 13, as a white solid, m.p.: 67°-68° C.

Workup

  1. extractionextracted with ether
  2. customThe extract was dried
  3. concentrationconcentrated
  4. customThe residue was crystallized from ether-hexane

Sources & evidence

ORD record
ord-9b46802ee94f42039665730613d504db
Source dataset
uspto-grants-1984_03
Patent number
US04439226

Reaction notes

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