N-[(Diethoxyphosphoryl)methyl]glycine → Glyphosate

HRID 1903898Notes

Reaction equation

HRID 1903898 reaction equation
C([O:3][P:4]([CH2:9][NH:10][CH2:11][C:12]([OH:14])=[O:13])([O:6]CC)=[O:5])C>Cl>[CH2:11]([NH:10][CH2:9][P:4]([OH:6])([OH:5])=[O:3])[C:12]([OH:14])=[O:13]

Participants

3

Reactant 1

HCID 12633685N-[(Diethoxyphosphoryl)methyl]glycine

Product 1

HCID 3496Glyphosate

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

Diethylphosphonomethyl glycine (6 g) was refluxed, for 16 hours, with concentrated hydrochloric acid (20 ml). The reaction mixture was cooled and the solvent was evaporated to obtain glyphosate, which was confirmed by high pressure liquid chromatograph and 31P-nuclear magnetic resonance and infrared spectra.

Workup

  1. temperatureThe reaction mixture was cooled
  2. customthe solvent was evaporated

Sources & evidence

ORD record
ord-e3018e0491f94b339c46f88ee9e2d574
Source dataset
uspto-grants-1984_03
Patent number
US04439373

Reaction notes

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