5-Aminopentan-1-ol → HCID 12783829, compound

HRID 1903915Notes

Reaction equation

HRID 1903915 reaction equation
[N+]([NH:4][C:5]1[NH:10][C:9](=[O:11])[C:8]([CH2:12][C:13]2[CH:14]=[N:15][C:16]([CH3:19])=[CH:17][CH:18]=2)=[CH:7][N:6]=1)([O-])=O.N[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][OH:26]>N1C=CC=CC=1>[OH:26][CH2:25][CH2:24][CH2:23][CH2:22][CH2:21][NH:4][C:5]1[NH:10][C:9](=[O:11])[C:8]([CH2:12][C:13]2[CH:14]=[N:15][C:16]([CH3:19])=[CH:17][CH:18]=2)=[CH:7][N:6]=1

Participants

4

Reactant 2

HCID 756345-Aminopentan-1-olHCID 30183605-((6-Methyl-3-pyridyl)methyl)-2-(nitroamino)-1H-pyrimidin-4-one

Product 1

HCID 12783829HCID 12783829, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Reaction of 2-nitroamino-5-(6-methyl-3-pyridylmethyl)-4-pyrimidone with 5-aminopentanol in refluxing pyridine gives 2-(5-hydroxypentylamino)-5-(6-methyl-3-pyridylmethyl)-4-pyrimidone which can be converted into 2-[5-(O-isoureido)pentylamino]-5-(6-methyl-3-pyridylmethyl)-4-pyrimidone by the procedure of Example 5(iii).

Sources & evidence

ORD record
ord-258d690de2824b5b9d1c13a9181943d3
Source dataset
uspto-grants-1984_03
Patent number
US04439435

Reaction notes

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