Hydrochloric Acid → HCID 131713447, compound

HRID 1904035Notes

Reaction equation

HRID 1904035 reaction equation
[OH-].[Na+].[NH:3]([C:38]([O:40][CH2:41][C:42]1[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=1)=[O:39])[C@H:4]([C:11]([NH:13][C@H:14]([C:21]([NH:23][C@H:24]([C:29]([NH:31][C@H:32]([C:34]([O:36]C)=[O:35])[CH3:33])=[O:30])[CH2:25][C:26](=[O:28])[NH2:27])=[O:22])[CH2:15][O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:12])[CH2:5][O:6][C:7]([CH3:10])([CH3:9])[CH3:8].Cl>CO>[NH:3]([C:38]([O:40][CH2:41][C:42]1[CH:43]=[CH:44][CH:45]=[CH:46][CH:47]=1)=[O:39])[C@H:4]([C:11]([NH:13][C@H:14]([C:21]([NH:23][C@H:24]([C:29]([NH:31][C@H:32]([C:34]([OH:36])=[O:35])[CH3:33])=[O:30])[CH2:25][C:26](=[O:28])[NH2:27])=[O:22])[CH2:15][O:16][C:17]([CH3:19])([CH3:18])[CH3:20])=[O:12])[CH2:5][O:6][C:7]([CH3:8])([CH3:9])[CH3:10]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 131713448HCID 131713448, compound

Product 1

HCID 131713447HCID 131713447, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

34 ml of 0.5 N-sodium hydroxide is added to 3.54 g of Z-Ser(But)Ser(But)-Asn-Ala-OMe in 34 ml of methanol. After 3 minutes 17 ml of 1 N-hydrochloric acid is added, the methanol is removed by evaporation for the most part and the product which has separated out is filtered. By crystallization from methanol-ether there is obtained pure Z-Ser(But)-Ser(But)-Asn-Ala-OH of melting point 180°-181°.

Workup

  1. customthe methanol is removed by evaporation for the most part
  2. customthe product which has separated out
  3. filtrationis filtered
  4. customBy crystallization from methanol-ether

Sources & evidence

ORD record
ord-83b9c08cc02c495c8cef34a974761538
Source dataset
uspto-grants-1984_03
Patent number
US04439425

Reaction notes

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