反应详情

4.8 g of docosanyl-p-toluenesulfonate and 5 g of potassium carbonate are added to 3.6 g of N-palmitoyl-(L)-cysteine in 50 ml of ethanol. The mixture is heated under stirring and in a nitrogen atmosphere at 80° for 20 hours. After evaporating to dryness the residue is acidified with 1 N HCl so as to obtain a pH of about 3 and then it is distributed between chloroform and water. After having dried and evaporated the chloroform layer a colourless crystalline residue is obtained, which is recrystallized from ethyl acetate. There is thus obtained the N-palmitoyl-S-docosanyl-(L)-cysteine.

1. temperatureThe mixture is heated
2. customAfter evaporating to dryness the residue
3. customto obtain a pH of about 3
4. customAfter having dried
5. customevaporated the chloroform layer a colourless crystalline residue
6. customis obtained
7. customwhich is recrystallized from ethyl acetate