Hydrochloric Acid → Piperazine, 1-(4-chlorophenyl)-4-(phenylacetyl)-

Participants

Reaction Steps

To a cold solution of 8.09 g. of p-chlorophenyl piperazine dihydrochloride and 40 ml. of 10% sodium hydroxide in 60 ml. of water was added dropwise with stirring, 4.64 g. of phenylacetyl chloride. The mixture was stirred for one hour, then neutralized with 2 N hydrochloric acid. The solid was collected and recrystallized from ethanol-water, giving 4.2 g. of the desired product, m.p. 93°-94° C.

Provenance & Evidence