Hydrochloric Acid → HCID 178483281, compound

HRID 1904084Notes

Reaction equation

HRID 1904084 reaction equation
[CH3:1][N:2]([CH2:4][C:5]1[CH:10]=[CH:9][N:8]=[C:7]([CH2:11][S:12][CH2:13][CH2:14][NH:15][C:16]2[NH:21][C:20](=[O:22])[C:19]([CH2:23][C:24]3[CH:29]=[CH:28][N:27]=[C:26]([O:30]C)[CH:25]=3)=[CH:18][N:17]=2)[CH:6]=1)[CH3:3].[ClH:32]>C(O)C>[ClH:32].[ClH:32].[ClH:32].[ClH:32].[CH3:1][N:2]([CH2:4][C:5]1[CH:10]=[CH:9][N:8]=[C:7]([CH2:11][S:12][CH2:13][CH2:14][NH:15][C:16]2[NH:21][C:20](=[O:22])[C:19]([CH2:23][C:24]3[CH:29]=[CH:28][N:27]=[C:26]([OH:30])[CH:25]=3)=[CH:18][N:17]=2)[CH:6]=1)[CH3:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 132926052-(4-Dimethylaminomethyl-2-pyridylmethylthio)ethylamino-5-(2-methoxy-4-pyridylmethyl)-4-pyrimidone

Product 1

HCID 178483281HCID 178483281, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The product from Example 3, 2-[2-(4-dimethylaminomethyl-2-pyridylmethylthio)ethylamino]-5-(2-methoxy-4-pyridylmethyl)-4-pyrimidone was heated under reflux in 2 N hydrogen chloride in ethanol to give 2-[2-(4-dimethylaminomethyl-2-pyridylmethylthio)ethylamino]-5-(2-hydroxy-4-pyridylmethyl)-4-pyrimidone tetrahydrochloride.

Sources & evidence

ORD record
ord-c12d24c9507244f396afedd13d218cbb
Source dataset
uspto-grants-1984_03
Patent number
US04439609

Reaction notes

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