Sodium ethoxide → 2-[2-(4-Dimethylaminomethyl-2-pyridylmethylthio)ethylamino]-5-(6-methyl-3-pyridylmethyl)-4-pyrimidone

HRID 1904086Notes

Reaction equation

HRID 1904086 reaction equation
S(O)(O)(=O)=O.[CH3:6][N:7]([CH2:9][C:10]1[CH:15]=[CH:14][N:13]=[C:12]([CH2:16][S:17][CH2:18][CH2:19][NH:20][C:21]([NH2:23])=[NH:22])[CH:11]=1)[CH3:8].CN(C[C:28]1[CH:33]=[CH:32][N:31]=[C:30]([CH2:34]SCCNC(N)=N)[CH:29]=1)C.[CH:42]([CH:44]([CH2:50]CC1C=NC(C)=CC=1)[C:45](OCC)=O)=[O:43].[O-]CC.[Na+]>C(O)C>[CH3:8][N:7]([CH2:9][C:10]1[CH:15]=[CH:14][N:13]=[C:12]([CH2:16][S:17][CH2:18][CH2:19][NH:20][C:21]2[NH:23][C:42](=[O:43])[C:44]([CH2:50][C:33]3[CH:32]=[N:31][C:30]([CH3:34])=[CH:29][CH:28]=3)=[CH:45][N:22]=2)[CH:11]=1)[CH3:6]

Participants

5

Reactant 3

HCID 2723922Sodium ethoxideHCID 20239077HCID 20239077, compoundHCID 178483283HCID 178483283, compound

Product 1

HCID 132926042-[2-(4-Dimethylaminomethyl-2-pyridylmethylthio)ethylamino]-5-(6-methyl-3-pyridylmethyl)-4-pyrimidone

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Reaction of N-[2-(4-dimethylaminomethyl-2-pyridylmethylthio)ethyl]guanidine hemisulphate with ethyl 2-formyl-3-(6-methyl-3-pyridylmethyl)propionate and sodium ethoxide in ethanol gives 2-[2-(4-dimethylaminomethyl-2-pyridyl-methylthio)ethylamino]-5-(6-methyl-3-pyridylmethyl)-4-pyrimidone.

Sources & evidence

ORD record
ord-57aec45b81354032b99e9de6c03e6bb9
Source dataset
uspto-grants-1984_03
Patent number
US04439609

Reaction notes

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