Sodium Hydroxide → HCID 74088766, compound

HRID 1904137Notes

Reaction equation

HRID 1904137 reaction equation
[C:1]([NH:20][C:21]1[S:22][CH:23]=[C:24]([C:26](=[N:32][O:33][CH2:34][CH2:35][Br:36])[C:27]([O:29]CC)=[O:28])[N:25]=1)([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+:38]>C(O)C>[C:1]([NH:20][C:21]1[S:22][CH:23]=[C:24]([C:26](=[N:32][O:33][CH2:34][CH2:35][Br:36])[C:27]([O-:29])=[O:28])[N:25]=1)([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Na+:38]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 53679114Ethyl 2-(bromoethoxyimino)-2-(2-tritylamino-4-thiazolyl)-acetate

Product 1

HCID 74088766HCID 74088766, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

28.2 g of ethyl 2-(2-tritylamino-4-thiazolyl)-2-(2-bromoethoxyimino)-acetate were added to a mixture of 6 g of sodium hydroxide pastilles in 280 ml of absolute ethanol and the mixture was stirred at room temperature for 65 hours and was vacuum filtered. The recovered product was washed with ethanol and dried under reduced pressure to obtain 29.2 g of the syn isomer of sodium 2-(2-tritylamino-4-thiazolyl)-2-(2-bromoethoxyimino)-acetate, solvated at 12%.

Workup

  1. filtrationfiltered
  2. washThe recovered product was washed with ethanol
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-11a7502b00b44107b5edf0c59ddab93d
Source dataset
uspto-grants-1984_03
Patent number
US04439433

Reaction notes

Loading…