Ethanol → HCID 131713475, compound

HRID 1904146Notes

Reaction equation

HRID 1904146 reaction equation
C(O)C.[CH3:4][N:5]1[C:9]([S:10][CH2:11][C:12]2[CH2:13][S:14][C@@H:15]3[CH:22]([NH:23][C:24](=[O:39])[C:25]([C:33]4[N:34]=[C:35]([NH2:38])[S:36][CH:37]=4)=[N:26][O:27][CH2:28][CH2:29][N:30]=[N+:31]=[N-:32])[C:21](=[O:40])[N:16]3[C:17]=2[C:18]([OH:20])=[O:19])=[N:8][N:7]=[N:6]1.C(=O)(O)[O-].[Na+:45]>O>[CH3:4][N:5]1[C:9]([S:10][CH2:11][C:12]2[CH2:13][S:14][C@@H:15]3[CH:22]([NH:23][C:24](=[O:39])[C:25]([C:33]4[N:34]=[C:35]([NH2:38])[S:36][CH:37]=4)=[N:26][O:27][CH2:28][CH2:29][N:30]=[N+:31]=[N-:32])[C:21](=[O:40])[N:16]3[C:17]=2[C:18]([O-:20])=[O:19])=[N:8][N:7]=[N:6]1.[Na+:45]

Participants

5

Reactant 3

HCID 702EthanolHCID 516892Sodium BicarbonateHCID 131713474HCID 131713474, compound

Product 1

HCID 131713475HCID 131713475, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

1 ml of ethanol was added to a solution of 0.162 g of the product of Example 36 in 0.3 ml of a molar solution of sodium bicarbonate in water and the mixture was vacuum filtered. The filtrate was evaporated to dryness undere reduced pressure and the residue was taken up in ethanol. After efflorescence, the mixture was vaccum filtered to obtain 0.09 g of the syn isomer of sodium 3-[(1-methyl-1H-tetrazol-5-yl)-thiomethyl]-7-[2-(2-amino-4-thiazolyl)-2-(2-azidoethoxyimino)-acetamido]-ceph-3-eme-4-carboxylate.

Workup

  1. filtrationfiltered
  2. customThe filtrate was evaporated to dryness undere reduced pressure
  3. filtrationAfter efflorescence, the mixture was vaccum filtered

Sources & evidence

ORD record
ord-9b7ce19e658b443ab58da3e990f4a22c
Source dataset
uspto-grants-1984_03
Patent number
US04439433

Reaction notes

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