Methacryloyl chloride → HCID 178454440, compound

HRID 1904190Notes

Reaction equation

HRID 1904190 reaction equation
[NH2:1][C:2]1[CH:10]=[CH:9][C:5]2[NH:6][N:7]=[N:8][C:4]=2[CH:3]=1.[C:11](Cl)(=[O:15])[C:12]([CH3:14])=[CH2:13]>C(#N)C.N1C=CC=CC=1>[C:11]([NH:1][C:2]1[CH:10]=[CH:9][C:5]2[NH:6][N:7]=[N:8][C:4]=2[CH:3]=1)(=[O:15])[C:12]([CH3:14])=[CH2:13]

Participants

5

Reactant 2

HCID 13528Methacryloyl chlorideHCID 178507366HCID 178507366, compound

Product 1

HCID 178454440HCID 178454440, compound

Reagents, catalysts & solvents 2

HCID 1049PyridineSolventHCID 6342AcetonitrileSolvent

Procedure

After 26.8 g of 5-aminobenzotriazole was dissolved in a mixture of acetonitrile (300 ml) and pyridine (40 ml), 46.5 g of methacrylic acid chloride was added dropwise. The resulting solution was concentrated and 200 ml of a 10% aqueous solution of sodium hydroxide was added. After the mixture was agitated for 30 minutes, it was neutralized with dilute hydrochloric acid and the end compound was obtained as a solid precipitate in an amount of 27.3 g (yield, 6.7%).

Workup

  1. additionwas added dropwise
  2. concentrationThe resulting solution was concentrated
  3. addition200 ml of a 10% aqueous solution of sodium hydroxide was added
  4. customthe end compound was obtained as a solid precipitate in an amount of 27.3 g (yield, 6.7%)

Sources & evidence

ORD record
ord-fef106d140e54f95853adcca1de58594
Source dataset
uspto-grants-1989_06
Patent number
US04837141

Reaction notes

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