HRID1904197

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8471

Triethylamine

C6H15N

HCID76300

Ethyl 4-bromobutyrate

C6H11BrO2

HCID11961924

(2S)-2-Aminobutanamide--hydrogen chloride (1/1)

C4H11ClN2O

PRODUCTS

生成物

HCID29938336

Ethyl 4-[[(1S)-1-(aminocarbonyl)propyl]amino]butanoate

C10H20N2O3

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID1140

Toluene

C7H8

CONDITIONS

反应条件

温度: 80 °C

PROCEDURE

实验过程

143.6 ml (1.035 mole) of triethylamine are added to a suspension of 47.75 g (0.345 mole) of (S)-2-amino-butanamide hydrochloride ([alpha]D25 : +26.1°; c=1, methanol) in 400 ml of toluene. The mixture is heated to 80° C. and 67.2 g (0.345 mole) of ethyl 4-bromobutyrate are introduced dropwise.