Hydrochloric Acid → HCID 13770052, compound

HRID 1904220Notes

Reaction equation

HRID 1904220 reaction equation
[CH3:1][C:2]1[N:3]([CH2:8][CH2:9][NH:10][C:11]([NH:13][C:14]2[CH:19]=[CH:18][C:17]([C:20]([O:22]CC)=[O:21])=[CH:16][CH:15]=2)=[O:12])[C:4]([CH3:7])=[CH:5][CH:6]=1.[OH-].[Na+].Cl>CO>[CH3:7][C:4]1[N:3]([CH2:8][CH2:9][NH:10][C:11]([NH:13][C:14]2[CH:15]=[CH:16][C:17]([C:20]([OH:22])=[O:21])=[CH:18][CH:19]=2)=[O:12])[C:2]([CH3:1])=[CH:6][CH:5]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 13770051HCID 13770051, compound

Product 1

HCID 13770052HCID 13770052, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

3.3 g (0.01 mol) of N-(2-(2,5-dimethyl-1-pyrrolyl)ethyl)-N'-(4-ethoxycarbonylphenyl)urea, prepared as in Example 7, are stirred with 12 ml of methanol and 10 ml of 1 N sodium hydroxide solution at room temperature for 1 h and then acidified with dilute hydrochloric acid. The precipitated product is filtered off with suction and dried. Yield: 1.5 g (50% of theory), Melting point: 248°-250° C. Elemental analysis: C16H19N3O3 (301.35) calculated: C 63.8 H 6.4 N 13.9 O 15.9 found: C 63.4 H 6.2 N 13.9 O 16.3

Workup

  1. filtrationThe precipitated product is filtered off with suction
  2. customdried

Sources & evidence

ORD record
ord-3e77b613a2434aba8cef14c6e54a5430
Source dataset
uspto-grants-1989_06
Patent number
US04837225

Reaction notes

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