Hydrochloric Acid → HCID 13770056, compound

HRID 1904224Notes

Reaction equation

HRID 1904224 reaction equation
[NH2:1][CH2:2][CH2:3][N:4]1[C:8]([CH3:9])=[CH:7][CH:6]=[C:5]1[CH3:10].Cl.[O-:12][C:13]#[N:14].[K+]>O>[CH3:10][C:5]1[N:4]([CH2:3][CH2:2][NH:1][C:13]([NH2:14])=[O:12])[C:8]([CH3:9])=[CH:7][CH:6]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 11378442Potassium cyanateHCID 137700502-(2,5-Dimethyl-1H-pyrrol-1-yl)ethan-1-amine

Product 1

HCID 13770056HCID 13770056, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

6.9 g (0.05 mol) of 1-(2-aminoethyl)2,5-dimethylpyrrole are dissolved in 8 ml of water. While cooling, 5 ml of concentrated hydrochloric acid are slowly added dropwise, and then 4.9 g (0.05 mol) of potassium cyanate, dissolved in 30 ml of water, are added dropwise. The precipitated solid is filtered off with suction and recrystallized from toluene/ethyl acetate. Yield: 3.8 g (42% of theory), Melting point: 139°-141° C. Elemental analysis: C9H15N3O (181.24) calculated: C 59.6 H 8.3 N 23.2 0 8.8 found: C 59.2 H 8.2 N 22.8 0 9.1

Workup

  1. temperatureWhile cooling
  2. additionare added dropwise
  3. filtrationThe precipitated solid is filtered off with suction
  4. customrecrystallized from toluene/ethyl acetate

Sources & evidence

ORD record
ord-a76f235e6e1546bb9456884c9f1e71e0
Source dataset
uspto-grants-1989_06
Patent number
US04837225

Reaction notes

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