4-(2-Ethoxy-1-ethylethoxy)-benzyl bromide → 2-t-butyl-4-chloro-5-[4-(2-ethoxy-1-ethylethoxy)-benzyloxy]-3(2H)-pyridazinone

HRID 1904242Notes

Reaction equation

HRID 1904242 reaction equation
[C:1]([N:5]1[C:10](=[O:11])[C:9]([Cl:12])=[C:8]([OH:13])[CH:7]=[N:6]1)([CH3:4])([CH3:3])[CH3:2].[CH2:14]([O:16][CH2:17][CH:18]([CH2:28][CH3:29])[O:19][C:20]1[CH:27]=[CH:26][C:23]([CH2:24]Br)=[CH:22][CH:21]=1)[CH3:15]>>[C:1]([N:5]1[C:10](=[O:11])[C:9]([Cl:12])=[C:8]([O:13][CH2:24][C:23]2[CH:22]=[CH:21][C:20]([O:19][CH:18]([CH2:28][CH3:29])[CH2:17][O:16][CH2:14][CH3:15])=[CH:27][CH:26]=2)[CH:7]=[N:6]1)([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 146718094-(2-Ethoxy-1-ethylethoxy)-benzyl bromideHCID 546869462-tert-Butyl-4-chloro-5-hydroxypyridazin-3(2H)-one

Product 1

HCID 146718102-t-butyl-4-chloro-5-[4-(2-ethoxy-1-ethylethoxy)-benzyloxy]-3(2H)-pyridazinoneYield 24.8%

Procedure

Procedures similar to those in Preparation Example 8 were carried out by using 2.0 g of 2-t-butyl-4-chloro-5-hydroxy-3(2H)-pyridazinone and 3.1 g of 4-(2-ethoxy-1-ethylethoxy)-benzyl bromide to obtain 1.0 g of the aimed compound as an oil.

Workup

  1. customProcedures similar to those in Preparation Example 8

Sources & evidence

ORD record
ord-77bd14a7fc494bff9c29a9a57cdfd1b1
Source dataset
uspto-grants-1989_06
Patent number
US04837217

Reaction notes

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