Sodium Hydroxide → HCID 13747175, compound

HRID 1904261Notes

Reaction equation

HRID 1904261 reaction equation
[CH2:1]([NH:4][C:5]1[C:10]([C:11]([O:13]CC)=[O:12])=[CH:9][N:8]=[C:7]2[CH:16]=[N:17][NH:18][C:6]=12)[CH:2]=[CH2:3].[OH-].[Na+]>O>[CH2:1]([NH:4][C:5]1[C:10]([C:11]([OH:13])=[O:12])=[CH:9][N:8]=[C:7]2[CH:16]=[N:17][NH:18][C:6]=12)[CH:2]=[CH2:3]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 13747174HCID 13747174, compound

Product 1

HCID 13747175HCID 13747175, compoundYield 97.4%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Ethyl 7-allylamino-1H-pyrazolo[4,3-b]pyridine-6-carboxylate (5.0 g, 20 mmol) was added to a solution of sodium hydroxide (2.4 g, 60 mmol) in water (100 ml) and heated under reflux for 60 min. The solution was filtered, diluted with water (200 ml) and made neutral with 5N hydrochloric acid. The solid was filtered off, washed with water and dried to give the title compound (4.25 g, 96%), m.p. 240°-242° C.

Workup

  1. temperatureheated
  2. temperatureunder reflux for 60 min
  3. filtrationThe solution was filtered
  4. additiondiluted with water (200 ml)
  5. filtrationThe solid was filtered off
  6. washwashed with water
  7. customdried

Sources & evidence

ORD record
ord-3713893392a240aab65c48098d0a2b03
Source dataset
uspto-grants-1989_06
Patent number
US04837238

Reaction notes

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