反应详情

温度

80 °C

A mixture of 6-acetyl-4,7-dihydro-7-oxo-1H-pyrazolo-[4,3-b]pyridine (D14, 1.6 g, 9 mmol) and phosphorus oxychloride (15 ml) was heated at 80° C. for 30 min. Excess reagent was removed in vacuo, water was added and the mixture was adjusted to pH 9 with 10% sodium carbonate solution. The resulting mixture was extracted with ethyl acetate (4×50 ml), and the extracts were washed with brine, dried (MgSO4) and evaporated in vacuo to leave the title compound as a yellow solid, which was used without further purification.

1. customExcess reagent was removed in vacuo, water
2. additionwas added
3. extractionThe resulting mixture was extracted with ethyl acetate (4×50 ml)
4. washthe extracts were washed with brine
5. dry with materialdried (MgSO4)
6. customevaporated in vacuo