Hydrochloric Acid → HCID 20038770, compound

HRID 1904274Notes

Reaction equation

HRID 1904274 reaction equation
[CH2:1]([NH:4][C:5]1[C:6]2[C:7](=[CH:13][N:14](C(OC)(C)C)[N:15]=2)[N:8]=[CH:9][C:10]=1[CH2:11][OH:12])[CH:2]=[CH2:3].Cl.C(=O)([O-])[O-].[Na+].[Na+]>O>[CH2:1]([NH:4][C:5]1[C:10]([CH2:11][OH:12])=[CH:9][N:8]=[C:7]2[CH:13]=[N:14][NH:15][C:6]=12)[CH:2]=[CH2:3]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 10340Sodium CarbonateHCID 20038774HCID 20038774, compound

Product 1

HCID 20038770HCID 20038770, compoundYield 93%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

7-Allylamino-6-hydroxymethyl-2-(2-methoxy-2-propyl)-2H-pyrazolo[4,3-b]pyridine (1.30 g, 4.7 mmol) was suspended in water (15 ml) and made acidic with 6N hydrochloric acid. After 45 min the solution was adjusted to pH 9 with 10% sodium carbonate solution. The precipitated solid was filtered off and dried to give the title compound (0.89 g, 93%), m.p. 190°-192° C. Found: C, 58.58; H, 5.62; N, 27.25 C10H12N4O requires C, 58.81; H, 5.92; N, 27.43%

Workup

  1. filtrationThe precipitated solid was filtered off
  2. customdried

Sources & evidence

ORD record
ord-8058a4bef86742b5b1472822cca85691
Source dataset
uspto-grants-1989_06
Patent number
US04837238

Reaction notes

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