反应详情

To a solution of 0.82 g (5.07 mmol) of 1,1-dimethyl-4-aminoindan and 0.48 g (6.08 mmol) of pyridine in 10 ml of tetrahydrofuran was added dropwise with stirring below 5° C. under ice cooling, a solution of 0.99 g (5.07 mmol) of 2-chloro-4-methylthiazole-5-carboxylic acid chloride in 3 ml of tetrahydrofuran, followed by stirring at room temperature overnight. The reaction mixture was poured into water and extracted with ethyl acetate. The organic layer was washed with 5% hydrochloric acid and then water and was dried over anhydrous sodium sulfate. The solvent was distilled off to obtain crystals, which was washed with n-hexane and dried to obtain 1.51 g of N-(1,1-dimethyl-4-indanyl)-2-chloro-4-methylthiazole-5-carboxamide (yeild 93%).

1. stirringby stirring at room temperature overnight
2. extractionextracted with ethyl acetate
3. washThe organic layer was washed with 5% hydrochloric acid
4. dry with materialwater and was dried over anhydrous sodium sulfate
5. distillationThe solvent was distilled off
6. customto obtain crystals, which
7. washwas washed with n-hexane
8. customdried