反应详情

0.20 g of N-(1,1,3-trimethyl-4-indanyl)-2-methyl-4-trifluoromethylthiazole-5-carboxamide and 0.18 g of 2,4-bis(methylthio)-1,3,2,4-dithiadiphosphetan-2,4-disulfide were dissolved in 5 ml of tetrahydrofuran and reaction was effected for 10 hours under reflux. The reaction mixture was concentrated and the residue was chromatographed on silica gel (eluent; n-hexane:chloroform:tetrahydrofuran=6:2:1) to obtain 0.14 g of N-(1,1,3-trimethyl-4-indanyl)-2-methyl-4-trifluoromethylthiazole-5-carbothioamide (yield 65%).

1. customreaction
2. temperatureunder reflux
3. concentrationThe reaction mixture was concentrated
4. customthe residue was chromatographed on silica gel (eluent; n-hexane:chloroform:tetrahydrofuran=6:2:1)