Thionyl Chloride → 2-Methyl-4-(trifluoromethyl)-5-thiazolecarbonyl chloride

HRID 1904296Notes

Reaction equation

HRID 1904296 reaction equation
[CH3:1][C:2]1[S:3][C:4]([C:11]([OH:13])=O)=[C:5]([C:7]([F:10])([F:9])[F:8])[N:6]=1.S(Cl)([Cl:16])=O>>[CH3:1][C:2]1[S:3][C:4]([C:11]([Cl:16])=[O:13])=[C:5]([C:7]([F:10])([F:9])[F:8])[N:6]=1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 14860802-Methyl-4-(trifluoromethyl)-1,3-thiazole-5-carboxylic acid

Product 1

HCID 146010812-Methyl-4-(trifluoromethyl)-5-thiazolecarbonyl chloride

Procedure

0.50 g of 2-methyl-4-trifluoromethylthiazole-5-carboxylic acid was added to 5 ml of thionyl chloride and reaction was carried out for 2 hours under reflux. After the reaction, the reaction mixture was concentrated to obtain 0.54 g of 2-methyl-4-trifluoromethylthiazole-5-carbonyl chloride.

Workup

  1. temperatureunder reflux
  2. customAfter the reaction
  3. concentrationthe reaction mixture was concentrated

Sources & evidence

ORD record
ord-304908544a1449b7aab3d6ad64b7afa6
Source dataset
uspto-grants-1989_06
Patent number
US04837242

Reaction notes

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