Ammonia → HCID 70362091, compound

HRID 1904300Notes

Reaction equation

HRID 1904300 reaction equation
[NH3:1].[Cl-:2].[CH3:3][NH+:4]1[CH2:9][CH2:8][C:7]([C:10]([O:12]CC)=O)=[CH:6][CH2:5]1>O>[Cl-:2].[CH3:3][NH+:4]1[CH2:9][CH2:8][C:7]([C:10](=[O:12])[NH2:1])=[CH:6][CH2:5]1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 70362234HCID 70362234, compound

Product 1

HCID 70362091HCID 70362091, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a solution of ammonia in water (25%) (50 ml) was added 1-methyl-4-ethoxycarbonyl-1,2,5,6-tetrahydropyridinium chloride (Lambrecht & Mutschler, Arzneimittel Forsch. (Drug Res.) 23, 1427 (1973)) (4.5 g; 21,9 mmol) and the mixture was stirred at room temperature for 20 hours. After evaporation in vacuo, the residue was recrystallized from methanol and ether. M.P. 191°-192° C.

Workup

  1. customAfter evaporation in vacuo
  2. customthe residue was recrystallized from methanol and ether

Sources & evidence

ORD record
ord-f960b234aebe470588d6f23d3b1f23a8
Source dataset
uspto-grants-1989_06
Patent number
US04837241

Reaction notes

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