1,3-Dibromopropane → HCID 20039067, compound

HRID 1904318Notes

Reaction equation

HRID 1904318 reaction equation
[CH2:1]1[C:6]2[NH:7][C:8]3[C:13]([C:5]=2[CH2:4][CH2:3][NH:2]1)=[CH:12][CH:11]=[CH:10][CH:9]=3.Br[CH2:15][CH2:16][CH2:17]Br.Br[CH2:20][CH2:21][CH2:22][N:23]1[CH2:35][CH2:34][C:33]2[C:32]3[C:27](=CC=C[CH:31]=3)[NH:26][C:25]=2[CH2:24]1.[F:36]C(F)(F)C1C=C(C=CC=1)CN1CCNCC1>>[F:36][C:15]1[CH:33]=[C:32]([CH:31]=[CH:17][CH:16]=1)[CH2:27][N:26]1[CH2:25][CH2:24][N:23]([CH2:22][CH2:21][CH2:20][N:2]2[CH2:3][CH2:4][C:5]3[C:13]4[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=4)[NH:7][C:6]=3[CH2:1]2)[CH2:35][CH2:34]1

Participants

5

Reactant 4

HCID 80011,3-DibromopropaneHCID 107838Tetrahydro-beta-carbolineHCID 20608551-(3-(Trifluoromethyl)benzyl)piperazineHCID 14230066HCID 14230066, compound

Product 1

HCID 20039067HCID 20039067, compound

Procedure

Following the procedure of Example 1, 2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole is alkylated with 1,3-dibromopropane. The intermediate 2,3,4,9-tetrahydro-2-(3-bromopropyl)-1H-pyrido[3,4-b]indole is then reacted with 1-[3-(trifluoromethyl)benzyl]piperazine to obtain the title compound.

Sources & evidence

ORD record
ord-c045dd31493b415886c2e2ee686c3c64
Source dataset
uspto-grants-1989_06
Patent number
US04837325

Reaction notes

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