1,2-Dichloroethane → HCID 20038991, compound

HRID 1904320Notes

Reaction equation

HRID 1904320 reaction equation
[NH:1]1[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH:2]1[CH2:8][C:9]1[CH:10]=[C:11]([CH:17]=[CH:18][CH:19]=1)[O:12][CH2:13][CH2:14][CH2:15][NH2:16].[Cl:20][CH2:21][C:22](O)=[O:23].C(Cl)CCl.O>ClCCl>[NH:1]1[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH:2]1[CH2:8][C:9]1[CH:10]=[C:11]([CH:17]=[CH:18][CH:19]=1)[O:12][CH2:13][CH2:14][CH2:15][NH:16][C:22](=[O:23])[CH2:21][Cl:20]

Participants

6

Reactant 4

HCID 111,2-DichloroethaneHCID 300Chloroacetic AcidHCID 962WaterHCID 20038988HCID 20038988, compound

Product 1

HCID 20038991HCID 20038991, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Conditions

Temperature
0 °C

Procedure

0.22 g of 3-{3-(1-perhydroazepinylmethyl)phenoxy}propylamine was dissolved in 10 ml of dichloromethane, and cooled in an ice bath. 0.1 g of monochloroacetic acid and 0.2 g of EDC were added to this solution, and stirred at 0° C. for 30 minutes then at room temperature overnight. 10 ml of water and 10 ml of dichloromethane were added to the reaction solution, and the organic layer was separated, dried over anhydrous magnesium sulfate, and the solvent was evaporated in vacuo to obtain colorless oily N-[3-{3-(1-perhydroazepinylmethyl)phenoxy}propyl]-2-chloroacetamide. Yield: 0.15 g. ##STR159##

Workup

  1. temperaturecooled in an ice bath
  2. customat room temperature
  3. customovernight
  4. customthe organic layer was separated
  5. dry with materialdried over anhydrous magnesium sulfate
  6. customthe solvent was evaporated in vacuo

Sources & evidence

ORD record
ord-9fa5a2745afd4e88952c25b8583fc911
Source dataset
uspto-grants-1989_06
Patent number
US04837316

Reaction notes

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