p-Toluenesulfonic acid → HCID 14326047, compound

HRID 1904352Notes

Reaction equation

HRID 1904352 reaction equation
[O:1]1[CH:7]2[CH:2]1[C:3]([CH3:10])([CH3:9])[CH2:4][C:5](=[O:8])[O:6]2.[CH3:11][C:12]([CH3:15])([OH:14])[CH3:13].C1(C)C=CC(S(O)(=O)=O)=CC=1>N1C=CC=CC=1>[CH3:11][C:12]([CH3:15])([O:14][CH:7]1[O:6][C:5](=[O:8])[CH2:4][C:3]([CH3:10])([CH3:9])[CH:2]1[OH:1])[CH3:13]

Participants

5

Reactant 3

HCID 6101p-Toluenesulfonic acidHCID 6386tert-ButanolHCID 545978HCID 545978, compound

Product 1

HCID 14326047HCID 14326047, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A mixture of 500 mg of 5,6-epoxy-4,4-dimethyl-tetrahydro-pyr-2-one, 5 ml of 1,1-dimethyl ethanol and 2.5 mg of p-toluene sulfonic acid was stirred for 41 hours at room temperature and 1 ml of pyridine was then added. The mixture was evaporated to dryness under reduced pressure to obtain 6-(1,1-dimethylethoxy)-5-hydroxy-4,4-dimethyl-tetrahydro-pyr-2-one which was used as is for the next step.

Workup

  1. customThe mixture was evaporated to dryness under reduced pressure

Sources & evidence

ORD record
ord-253a1ae5d865441983252edc7103e304
Source dataset
uspto-grants-1989_06
Patent number
US04837341

Reaction notes

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