HCID 13590265, compound → HCID 14459388, compound

HRID 1904419Notes

Reaction equation

HRID 1904419 reaction equation
[CH3:1][C:2]([CH3:15])([CH3:14])[CH2:3][CH2:4][CH2:5][CH:6]([OH:13])[CH2:7][N:8]1[CH:12]=[CH:11][N:10]=[CH:9]1.COC1C=CC(COCC(O)CN2C=CN=C2)=CC=1>>[CH3:1][C:2]([CH3:15])([CH3:14])[CH2:3][CH2:4][CH2:5][C:6](=[O:13])[CH2:7][N:8]1[CH:12]=[CH:11][N:10]=[CH:9]1

Participants

3

Reactant 2

HCID 13590265HCID 13590265, compoundHCID 20039097HCID 20039097, compound

Product 1

HCID 14459388HCID 14459388, compound

Procedure

Utilising the procedure described in Example 1c and employing α-(4,4-dimethylpentyl)-1H-imidazole-1-ethanol in lieu of α-[[(4-methoxyphenyl)methoxy]methyl]-1H-imidazole-1-ethanol yielded a crude product which was purified by column chromatography (silica gel, chloroform) to yield 6,6-dimethyl-1-(1H-imidazol-1-yl)-2-heptanone as a colourless crystalline solid, having a melting point of 45°-46° C. (ether-hexane) and the following structural characteristics:

Workup

  1. customyielded a crude product which
  2. customwas purified by column chromatography (silica gel, chloroform)

Sources & evidence

ORD record
ord-332e962f58404ab29a34a39adf12b6f1
Source dataset
uspto-grants-1989_06
Patent number
US04837333

Reaction notes

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