Methanol → 1,1,1-Trifluoro-3,3-dimethoxypropane
Reaction equation
[CH3:1][OH:2].[F:3][C:4]([F:8])([F:7])[CH:5]=[CH2:6].[O:9]1CCOC[CH2:10]1>Cl[Pd]Cl.[Al](O)(O)O>[CH3:10][O:9][CH:6]([O:2][CH3:1])[CH2:5][C:4]([F:8])([F:7])[F:3]Participants
6
Reactant 3
Product 1
Reagents, catalysts & solvents 2
Conditions
- Temperature
- 60 °C
Procedure
In a glass autoclave, a mixture of 150 g (4.69 mol) of methanol, 150 g of 1,4-dioxane, 3.0 g (0.017 mol) of PdCl2, 5.8 g (0.034 mol) of CuCl2.2H2O and 4.0 g of Al(OH)3 was kept heated at 60° C. Stirring the mixture, 3,3,3-trifluoropropene was continuously introduced into the autoclave so as to keep the gas pressure in the autoclave at 8 kg/cm2. This operation was continued for 10 hr. As the result 245.2 g (1.552 mol) of 1,1-dimethoxy-3,3,3-trifluoropropane was obtained. In this case selectivity to this acetal was 60.2%, and the remaining part of the reaction product was 3,3,3-trifluoropropanal.
Workup
- additionwas continuously introduced into the autoclave so as
Sources & evidence
- ORD record
- ord-b9947dac74834b989c2e9368fe575c64
- Source dataset
- uspto-grants-1989_06
- Patent number
- US04837366
Reaction notes
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