Methanol → 1,1,1-Trifluoro-3,3-dimethoxypropane

Participants

Reaction Conditions

Reaction Steps

In a glass autoclave, a mixture of 150 g (4.69 mol) of methanol, 150 g of 1,4-dioxane, 3.0 g (0.017 mol) of PdCl2, 5.8 g (0.034 mol) of CuCl2.2H2O and 4.0 g of Al(OH)3 was kept heated at 60° C. Stirring the mixture, 3,3,3-trifluoropropene was continuously introduced into the autoclave so as to keep the gas pressure in the autoclave at 8 kg/cm2. This operation was continued for 10 hr. As the result 245.2 g (1.552 mol) of 1,1-dimethoxy-3,3,3-trifluoropropane was obtained. In this case selectivity to this acetal was 60.2%, and the remaining part of the reaction product was 3,3,3-trifluoropropanal.

Provenance & Evidence