反应详情

A solution of (F') (0.56 g) in tetrahydrofuran (30 ml) was hydrogenated in the presence of palladium-on-carbon (10% w/w; 0.1 g), as described for the amino ester (H) in Example 4, to give methyl 4-(5-amino-1-methylindol-3-ylmethyl)-3-methoxybenzoate (S) (0.50 g, 98%) as pale yellow foam; NMR: 3.6(s, 3H, NCH3), 3.8(s, 3H, COOCH3), 3.9(br s, 5H, OCH3 and CH2Ar), 4.45(br, 2H, NH2), 6.54(m, 2H), 6.86(s, 1H), 7.04(m, 2H), 7.40(m, 2H).