Methyl 4-[5-(cyclopentyloxycarbonyl)amino-1-methylindazol-3-ylmethyl]-3-methoxybenzoate → 4-[5-(Cyclopentyloxycarbonyl)amino-1-methylindazol-3-ylmethyl]-3-methoxybenzoic acid

HRID 1904477Notes

Reaction equation

HRID 1904477 reaction equation
C1(N(C2C=CC=CC=2)C(OC(=O)C2C=CC(CN3C4C(=CC=C(NC(=O)C(CC)CCCC)C=4)C=C3)=C(OC)C=2)=O)C=CC=CC=1.[CH:47]1([O:52][C:53]([NH:55][C:56]2[CH:57]=[C:58]3[C:62](=[CH:63][CH:64]=2)[N:61]([CH3:65])[N:60]=[C:59]3[CH2:66][C:67]2[CH:76]=[CH:75][C:70]([C:71]([O:73]C)=[O:72])=[CH:69][C:68]=2[O:77][CH3:78])=[O:54])[CH2:51][CH2:50][CH2:49][CH2:48]1>>[CH:47]1([O:52][C:53]([NH:55][C:56]2[CH:57]=[C:58]3[C:62](=[CH:63][CH:64]=2)[N:61]([CH3:65])[N:60]=[C:59]3[CH2:66][C:67]2[CH:76]=[CH:75][C:70]([C:71]([OH:73])=[O:72])=[CH:69][C:68]=2[O:77][CH3:78])=[O:54])[CH2:48][CH2:49][CH2:50][CH2:51]1

Participants

3

Reactant 2

HCID 14626827Methyl 4-[5-(cyclopentyloxycarbonyl)amino-1-methylindazol-3-ylmethyl]-3-methoxybenzoateHCID 147530114-[6-(2-ethylhexanamido)indole-1-yl-methyl]-3-methoxybenzoic N,N-diphenylcarbamic anhydride

Product 1

HCID 146268294-[5-(Cyclopentyloxycarbonyl)amino-1-methylindazol-3-ylmethyl]-3-methoxybenzoic acid

Procedure

Using a similar procedure to that described in part (d) of Example 1, except starting from the ester (Y) instead of the ester (C), 4-[5-(cyclopentyloxycarbonyl)amino-1-methylindazol-3-ylmethyl]-3-methoxybenzoic acid (U) was obtained as a white solid (95%); mp 216°-217° C.

Sources & evidence

ORD record
ord-c194e3c84251419f9351895cc5cb020f
Source dataset
uspto-grants-1989_06
Patent number
US04837235

Reaction notes

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