Dimethylformamide → HCID 178472050, compound

HRID 1904606Notes

Reaction equation

HRID 1904606 reaction equation
[Br:1][C:2]1[C:15]([F:16])=[CH:14][C:5]([C:6]([CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])=[O:7])=[C:4]([F:17])[C:3]=1[F:18].[NH2:19][C@H:20]([CH3:23])[CH2:21][OH:22].[CH3:24]N(C)C=O>>[Br:1][C:2]1[C:15]([F:16])=[CH:14][C:5]([C:6]([C:8](=[CH:24][NH:19][C@H:20]([CH3:23])[CH2:21][OH:22])[C:9]([O:11][CH2:12][CH3:13])=[O:10])=[O:7])=[C:4]([F:17])[C:3]=1[F:18]

Participants

4

Reactant 3

HCID 6228DimethylformamideHCID 80308(R)-(-)-2-Amino-1-propanolHCID 14501381HCID 14501381, compound

Product 1

HCID 178472050HCID 178472050, compoundYield 91%

Procedure

was prepared from ethyl 4-bromo-2,3,5-trifluorobenzoylacetate, dimethylformamide and (R)-2-amino-1-propanol by the procedure of Example 1(d) and obtained in 91% yield as an orange oil.

Workup

  1. customobtained in 91% yield as an orange oil

Sources & evidence

ORD record
ord-40e336939b7542b68d6702797a1497fe
Source dataset
uspto-grants-1989_06
Patent number
US04839355

Reaction notes

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