Hydrochloric Acid → HCID 70384925, compound

HRID 1904608Notes

Reaction equation

HRID 1904608 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([C:8]2[C:9]([F:28])=[CH:10][C:11]3[C:21](=[O:22])[C:20]([C:23]([O:25]CC)=[O:24])=[CH:19][N:13]4[C@H:14]([CH3:18])[CH2:15][O:16][C:17]=2[C:12]=34)[CH:5]=[C:4]([CH3:29])[N:3]=1.Cl>>[CH3:29][C:4]1[CH2:5][C:6]([C:8]2[C:9]([F:28])=[CH:10][C:11]3[C:21](=[O:22])[C:20]([C:23]([OH:25])=[O:24])=[CH:19][N:13]4[C@H:14]([CH3:18])[CH2:15][O:16][C:17]=2[C:12]=34)([CH3:7])[CH:1]=[CH:2][N:3]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 14501366Ethyl (R)-10-(2,6-dimethyl-4-pyridinyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylate

Product 1

HCID 70384925HCID 70384925, compound

Procedure

[I; R and R'=H, R"=CH3 ] was prepared by hydrolysis of the ester of part (e) with hydrochloric acid according to the procedure of Example 1(h), and was obtained as a colorless solid, m.p. 308°-312° C. when recrystallized from methanol; [α]D25 =+40.7° (1% in chloroform).

Workup

  1. customwas obtained as a colorless solid, m.p. 308°-312° C. when
  2. customrecrystallized from methanol
  3. custom[α]D25 =+40.7° (1% in chloroform)

Sources & evidence

ORD record
ord-b4f1d403a1024a058da2d11837183110
Source dataset
uspto-grants-1989_06
Patent number
US04839355

Reaction notes

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