Hydrochloric Acid → HCID 178418687, compound

HRID 1904609Notes

Reaction equation

HRID 1904609 reaction equation
Cl[C:2]1[N:7]2[CH:8]=[CH:9][N:10]=[C:6]2[CH:5]=[CH:4][CH:3]=1.[SH2:11].[K].Cl>>[SH:11][C:2]1[N:7]2[CH:8]=[CH:9][N:10]=[C:6]2[CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 109537225-Chloroimidazo[1,2-A]pyridineHCID 86743134Potassium hydrogensulfide

Product 1

HCID 178418687HCID 178418687, compoundYield 33%

Procedure

A mixture of 2.5 g of 5-chloroimidazo[1,2-a]pyridine and 30 ml of 2N-potassium hydrogen sulfide solution is stirred at room temperature for 6 hours and then at 80° C. for 3 days. The pH of the reaction mixture is adjusted to 2 with concentrated hydrochloric acid. The reaction mixture is extracted twice with 200 ml of ethyl acetate, and dried over magnesium sulfate, followed by evaporation of the solvent under reduced pressure, and the resulting powder is collected by filtration. Yield:33%.

Workup

  1. waitat 80° C. for 3 days
  2. extractionThe reaction mixture is extracted twice with 200 ml of ethyl acetate
  3. dry with materialdried over magnesium sulfate
  4. customfollowed by evaporation of the solvent under reduced pressure
  5. filtrationthe resulting powder is collected by filtration

Sources & evidence

ORD record
ord-895706e00600439180f7fcf4291241c5
Source dataset
uspto-grants-1989_06
Patent number
US04839351

Reaction notes

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