反应详情

A mixture of 4.9 g (0.02M) of N-(3-mercapto-2-methyl propanoyl)-N-cyclopentyl glycine and 8 ml of phenyl isocyanate in 5 ml methylene chloride was stirred at room temperature for 72 hours. The mixture was diluted with ether and filtered. The ether solution was washed with water, dried over MgSO4 and evaporated to dryness. The crude residue was dissolved in acetonitrile, treated with charcoal and crystallized by addition of ether, m.p. 170°-172° C.

1. filtrationfiltered
2. washThe ether solution was washed with water
3. dry with materialdried over MgSO4
4. customevaporated to dryness
5. dissolutionThe crude residue was dissolved in acetonitrile
6. additiontreated with charcoal
7. customcrystallized by addition of ether, m.p. 170°-172° C.