HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenyl isocyanate → N-(3-Phenylcarbamoylthio-2-methyl-propanoyl)-N-cyclopentyl glycine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenyl isocyanate | HCID 7672 | — |
| Reactant | (S)-[Cyclopentyl-(3-mercapto-2-methyl-propionyl)-amino]-acetic acid | HCID 13469595 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-(3-Phenylcarbamoylthio-2-methyl-propanoyl)-N-cyclopentyl glycine | HCID 13469596 | — |
Reaction Steps
A mixture of 4.9 g (0.02M) of N-(3-mercapto-2-methyl propanoyl)-N-cyclopentyl glycine and 8 ml of phenyl isocyanate in 5 ml methylene chloride was stirred at room temperature for 72 hours. The mixture was diluted with ether and filtered. The ether solution was washed with water, dried over MgSO4 and evaporated to dryness. The crude residue was dissolved in acetonitrile, treated with charcoal and crystallized by addition of ether, m.p. 170°-172° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04839367 |
| Source dataset | uspto-grants-1989_06 |
| ORD ID | ord-4e4353bd8f7547899d389454002556e5 |
| Source note | uspto-grants-1989_06 |