Hydrochloric Acid → HCID 20037736, compound

HRID 1904636Notes

Reaction equation

HRID 1904636 reaction equation
C([O:3][C:4](=[O:20])[CH2:5][N:6]([C:12](=[O:19])[CH:13]([CH3:18])[CH2:14][S:15][CH2:16][CH3:17])[CH:7]1[CH2:11][CH2:10][CH2:9][CH2:8]1)C.Cl>[OH-].[Na+]>[CH2:16]([S:15][CH2:14][CH:13]([CH3:18])[C:12]([N:6]([CH:7]1[CH2:11][CH2:10][CH2:9][CH2:8]1)[CH2:5][C:4]([OH:20])=[O:3])=[O:19])[CH3:17]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 20037725HCID 20037725, compound

Product 1

HCID 20037736HCID 20037736, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

A mixture of 3.8 g (0.012) of N-(3-ethylthio-2-methyl propanoyl)-N-cyclopentyl glycine ethyl ester in 80 ml of 10% NaOH was stirred for 7 hours. It was then cooled, acidified with 10% HCl, extracted with ether, dried over MgSO4, and evaporated to dryness giving oily residue which was purified by HPLC using HOAc-EtOAc-Hexane (5:45:50).

Workup

  1. temperatureIt was then cooled
  2. extractionextracted with ether
  3. dry with materialdried over MgSO4
  4. customevaporated to dryness
  5. customgiving oily residue which
  6. customwas purified by HPLC

Sources & evidence

ORD record
ord-154ea921631046e68c258a585f7e5079
Source dataset
uspto-grants-1989_06
Patent number
US04839367

Reaction notes

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