反应详情

A mixture of 1.2 g (0.01 mol) 4-methoxyphenol, 3.2 g (0.01 mol) 2-(3-chloromethylphenoxymethyl)quinoline hydrochloride,, 2.8 g (0.02 mol) potassium carbonate and 2.8 g (0.017 mol) potassium iodide in 100 ml acetone was refluxed over a period of 24 hours. Reaction mixture was concentrated to dryness and slurried into water and extracted with ether. The ether extract was washed with water, dried over MgSO4 and concentrated to dryness under reduced pressure to obtain solid. Recrystallization from isopropanol yielded 2.1 g product, m.p. 83°-85° C.

1. temperaturewas refluxed over a period of 24 hours
2. customReaction mixture
3. concentrationwas concentrated to dryness
4. extractionextracted with ether
5. extractionThe ether extract
6. washwas washed with water
7. dry with materialdried over MgSO4
8. concentrationconcentrated to dryness under reduced pressure
9. customto obtain solid
10. customRecrystallization from isopropanol