Hydrochloric Acid → HCID 14501723, compound

Participants

Reaction Steps

To 1.5 g of 5[3-[3-(1-hydroxyhexyl)phenoxymethyl]-phenyl]2-carbethoxymethyl-2H-tetrazole in 5 ml of methanol was added 6.0 ml of 2N sodium hydroxide. The mixture was stirred for 3 hours. The mixture was acidified with hydrochloric acid and extracted with ether. On evaporation of the ether layer there was obtained 1.3 g of crude product. This was passed through a silica gel column and eluted with chloroform:methanol (4:1) to give 0.9 g of product as a light amber liquid.

Provenance & Evidence