Hydrochloric Acid → HCID 14501723, compound

HRID 1904674Notes

Reaction equation

HRID 1904674 reaction equation
[OH:1][CH:2]([C:8]1[CH:9]=[C:10]([CH:30]=[CH:31][CH:32]=1)[O:11][CH2:12][C:13]1[CH:14]=[C:15]([C:19]2[N:20]=[N:21][N:22](CC(OCC)=O)[N:23]=2)[CH:16]=[CH:17][CH:18]=1)[CH2:3][CH2:4][CH2:5][CH2:6][CH3:7].[OH-].[Na+].Cl>CO>[OH:1][CH:2]([C:8]1[CH:9]=[C:10]([CH:30]=[CH:31][CH:32]=1)[O:11][CH2:12][C:13]1[CH:14]=[C:15]([C:19]2[N:20]=[N:21][NH:22][N:23]=2)[CH:16]=[CH:17][CH:18]=1)[CH2:3][CH2:4][CH2:5][CH2:6][CH3:7]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 20037807HCID 20037807, compound

Product 1

HCID 14501723HCID 14501723, compoundYield 74.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To 1.5 g of 5[3-[3-(1-hydroxyhexyl)phenoxymethyl]-phenyl]2-carbethoxymethyl-2H-tetrazole in 5 ml of methanol was added 6.0 ml of 2N sodium hydroxide. The mixture was stirred for 3 hours. The mixture was acidified with hydrochloric acid and extracted with ether. On evaporation of the ether layer there was obtained 1.3 g of crude product. This was passed through a silica gel column and eluted with chloroform:methanol (4:1) to give 0.9 g of product as a light amber liquid.

Workup

  1. extractionextracted with ether
  2. customOn evaporation of the ether layer
  3. customthere was obtained 1.3 g of crude product
  4. washeluted with chloroform:methanol (4:1)

Sources & evidence

ORD record
ord-edf4d9df9b764e54a7662bdbf66eac20
Source dataset
uspto-grants-1989_06
Patent number
US04839369

Reaction notes

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