反应详情

In 25 ml of trifluoroacetic acid cooled in ice was dissolved 5.00 g of 9-amino-3,4-dihydroacridin-1(2H)-one. To the solution was added dropwise 6.70 ml (2.09 eq) of bisdimethylaminomethane over 5 minutes and thereafter the mixture was maintained at 90°-100° C. for 5 hours during which the starting material was converted to a mixture of intermediate and exo-methylene products. The reaction mixture was poured into ice/NaOH to make it basic and the precipitate was extracted with several portions of 5:1 dichloromethane/MeOH. The combined extracts were evaporated to a residue. The residue was refluxed in toluene for 5 hours during which the intermediate was converted to the end product. The reaction mixture was evaporated to a residue which was purified by chromatography on silica gel (EtOAc) to yield about 2 g of a solid. This was recrystallized from dichloromethane/EtOAc to yield 1.79 g (34%) of product as a solid, melting point 192°-193° C.

1. temperaturethe mixture was maintained at 90°-100° C. for 5 hours during which the starting material
2. additionwas converted to a mixture of intermediate and exo-methylene products
3. extractionthe precipitate was extracted with several portions of 5:1 dichloromethane/MeOH
4. customThe combined extracts were evaporated to a residue
5. temperatureThe residue was refluxed in toluene for 5 hours during which the intermediate
6. customThe reaction mixture was evaporated to a residue which
7. customwas purified by chromatography on silica gel (EtOAc)