Formaldehyde → HCID 53848450, compound

HRID 1904748Notes

Reaction equation

[S:1]1[C:5]2=[C:6]([CH2:10][S:11][C:12]3[NH:13][C:14]4[CH:20]=[CH:19][CH:18]=[CH:17][C:15]=4[N:16]=3)[N:7]=[CH:8][CH:9]=[C:4]2[CH:3]=[CH:2]1.[OH2:21].[CH2:22]=O>CC#N>[OH:21][CH2:22][N:16]1[C:15]2[CH:17]=[CH:18][CH:19]=[CH:20][C:14]=2[N:13]=[C:12]1[S:11][CH2:10][C:6]1[N:7]=[CH:8][CH:9]=[C:4]2[CH:3]=[CH:2][S:1][C:5]=12

Participants

Conditions

Temperature: 70 °C

Procedure

To 478.7 mg (1.60 mmol) of 2-[(thieno[2, 3-c]pyridin-7-yl)methylthio]benzimidazole. 1/10 H2O (Ia-1) were added 8 ml of CH3CN and 324.6 mg (4.00 mmol) of 37% aqueous solution of HCHO, and the mixture was stirred for 15 minutes at 70° C. After evaporation the solvent under reduced pressure, the residual crystals were washed with ether, whereby 420.9 mg (Yield : 80.3%) of the objective compound (Ib-4), 1-hydroxymethyl-2-[(thieno[2, 3-c]pyridin-7-yl)methylthio]benzimidazole was obtained as crystals.

Workup

customAfter evaporation the solvent under reduced pressure
washthe residual crystals were washed with ether, whereby 420.9 mg (Yield : 80.3%) of the objective compound (Ib-4)

Sources & evidence

ORD record: ord-a1ec240966654f709debedb1d50a3c60
Source dataset: uspto-grants-1989_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04839365

Reaction notes

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