Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | HCID 14461480 | HCID 14461480 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 53848450 | HCID 53848450 | — |
Reaction Steps
To 478.7 mg (1.60 mmol) of 2-[(thieno[2, 3-c]pyridin-7-yl)methylthio]benzimidazole. 1/10 H2O (Ia-1) were added 8 ml of CH3CN and 324.6 mg (4.00 mmol) of 37% aqueous solution of HCHO, and the mixture was stirred for 15 minutes at 70° C. After evaporation the solvent under reduced pressure, the residual crystals were washed with ether, whereby 420.9 mg (Yield : 80.3%) of the objective compound (Ib-4), 1-hydroxymethyl-2-[(thieno[2, 3-c]pyridin-7-yl)methylthio]benzimidazole was obtained as crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04839365 |
|---|
| Source dataset | uspto-grants-1989_06 |
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| ORD ID | ord-a1ec240966654f709debedb1d50a3c60 |
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| Source note | uspto-grants-1989_06 |
|---|
