HCID 14068929, compound → HCID 14068939, compound

HRID 1904782Notes

Reaction equation

HRID 1904782 reaction equation
[CH:1]([N:4]1[C:9](=[O:10])[CH:8]2[C:6]([C:11]3[CH:16]=[CH:15][C:14]([N+:17]([O-])=O)=[CH:13][CH:12]=3)([CH2:7]2)[C:5]1=[O:20])([CH3:3])[CH3:2]>C(O)C.[Pd]>[NH2:17][C:14]1[CH:13]=[CH:12][C:11]([C:6]23[CH2:7][CH:8]2[C:9](=[O:10])[N:4]([CH:1]([CH3:2])[CH3:3])[C:5]3=[O:20])=[CH:16][CH:15]=1

Participants

4

Reactant 1

HCID 14068929HCID 14068929, compound

Product 1

HCID 14068939HCID 14068939, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

Following the procedure of Example 3, a solution of 3-isopropyl-1-(4-nitrophenyl)-3-azabicyclo[3.1.0]hexane-2,4-dione in 100 ml of ethanol is hydrogenated in the presence of 0.17 g of 5% palladium on carbon and worked up, affording the title compound which melts at 160°-163° C. after recrystallisation from ethyl acetate/petroleum ether.

Sources & evidence

ORD record
ord-8a038a4a50814785bcd5a300cba3f4be
Source dataset
uspto-grants-1989_06
Patent number
US04839379

Reaction notes

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