反应详情

温度

100 °C

A mixture of 220 mg of 1-(4-aminophenyl)-1,2-cyclopropanedicarboxylic acid, 10 ml of methanol and 0.26 ml of methylamine (40%) is stirred in a glass bomb tube for 7 days at 100° C. The mixture is concentrated in vacuo and the residue is chromatographed over a column of silica gel with a 4:6 mixture of hexane/ethyl acetate. Recrystallisation from ethyl acetate/petroleum ether affords yellow crystals of the title compound, which is identical with the title compound of Example 3(a).

1. concentrationThe mixture is concentrated in vacuo
2. customthe residue is chromatographed over a column of silica gel with a 4:6 mixture of hexane/ethyl acetate
3. customRecrystallisation from ethyl acetate/petroleum ether