Thiourea → HCID 178505786, compound

HRID 1904815Notes

Reaction equation

HRID 1904815 reaction equation
NC(N)=[S:3].Cl[C:6]1[N:10]([CH2:11][C:12]2[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=2)[C:9]2[CH:19]=[CH:20][CH:21]=[CH:22][C:8]=2[N:7]=1>C(O)C>[F:18][C:15]1[CH:16]=[CH:17][C:12]([CH2:11][N:10]2[C:9]3[CH:19]=[CH:20][CH:21]=[CH:22][C:8]=3[N:7]=[C:6]2[SH:3])=[CH:13][CH:14]=1

Participants

4

Reactant 2

HCID 2723790ThioureaHCID 30202411-(4-Fluorobenzyl)-2-chlorobenzimidazole

Product 1

HCID 178505786HCID 178505786, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 8.35 parts of thiourea, 26 parts of 2-chloro-1-[(4-fluorophenyl)methyl]-1H-benzimidazole and 400 parts of ethanol was stirred and refluxed for 5 hours. The reaction mixture was evaporated. The residue was suspended in 2,2'-oxybispropane. The precipitated product was filtered off and crystallized from ethanol, yielding 6.1 parts of 1-[(4-fluorophenyl)methyl]-1H-benzimidazole-2-thiol; mp. 194.7° C. (62).

Workup

  1. temperaturerefluxed for 5 hours
  2. customThe reaction mixture was evaporated
  3. filtrationThe precipitated product was filtered off
  4. customcrystallized from ethanol

Sources & evidence

ORD record
ord-6d5e22122714489ab2c19ed8cb663bfd
Source dataset
uspto-grants-1989_06
Patent number
US04839374

Reaction notes

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