反应详情

To a stirred solution of 6 parts of 1,2-dimethyl-1H-benzimidazole in 50 parts of dry pyridine were added dropwise 6.2 parts of benzoyl chloride at room temperature. Upon completion, stirring was continued for 2 hours at room temperature. The whole was evaporated. The residue was dissolved in 260 parts of dichloromethane. Water was added and the solution was treated with concentrate ammonium hydroxide. The dichloromethane layer was decanted, dried, filtered and evaporated. The residue was taken up twice in 45 parts of methylbenzene and the latter was evaporated each time, yielding 1-benzoyl-1,4-dihydro-4-[(1-methyl-1H-benzimidazol-2-yl)methyl]pyridine as an oily residue (63).

1. customThe whole was evaporated
2. dissolutionThe residue was dissolved in 260 parts of dichloromethane
3. additionWater was added
4. additionthe solution was treated with concentrate ammonium hydroxide
5. customThe dichloromethane layer was decanted
6. customdried
7. filtrationfiltered
8. customevaporated
9. customthe latter was evaporated each time