反应详情

A mixture of 68 parts of ethyl 4-[[1-(2-thienylmethyl)-1H-benzimidazol-2-yl]methyl]-1-piperidinecarboxylate monohydrochloride, 95 parts of potassium hydroxide, 800 parts of 2-propanol and 10 parts of water was stirred and refluxed for 6 hours. The reaction mixture was evaporated and water was added to the residue. The product was extracted with methylbenzene. The extract was dried, filtered and evaporated. The residue was crystallized from 1,1'-oxybisethane. The product was filtered off and dried, yielding 27 parts (49%) of 2-(4-piperidinylmethyl)-1-(2-thienylmethyl)-1H-benzimidazole; mp. 117.4° C. (64).

1. temperaturerefluxed for 6 hours
2. customThe reaction mixture was evaporated
3. additionwater was added to the residue
4. extractionThe product was extracted with methylbenzene
5. customThe extract was dried
6. filtrationfiltered
7. customevaporated
8. customThe residue was crystallized from 1,1'-oxybisethane
9. filtrationThe product was filtered off
10. customdried