Hydrogen Bromide → HCID 14012877, compound

HRID 1904830Notes

Reaction equation

HRID 1904830 reaction equation
[S:1]1[CH:5]=[C:4]([CH2:6][N:7]2[C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=3[N:9]=[C:8]2[CH2:16][CH:17]2[CH2:22][CH2:21][N:20](C(OCC)=O)[CH2:19][CH2:18]2)[N:3]=[CH:2]1.[BrH:28]>>[BrH:28].[BrH:28].[BrH:28].[NH:20]1[CH2:19][CH2:18][CH:17]([CH2:16][C:8]2[N:7]([CH2:6][C:4]3[N:3]=[CH:2][S:1][CH:5]=3)[C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=3[N:9]=2)[CH2:22][CH2:21]1

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 14012873HCID 14012873, compound

Product 1

HCID 14012877HCID 14012877, compound

Procedure

A mixture of 2 parts of ethyl 4-[[1-(4-thiazolylmethyl)-1H-benzimidazol-2-yl]methyl]-1-piperidinecarboxylate and 30 parts of a hydrobromic acid solution 48% was stirred and refluxed for 15 minutes. The reaction mixture was evaporated. The oily residue was crystallized from a mixture of ethanol and 2-propanone, yielding 2 parts of 2-(4-piperidinylmethyl)-1-(4-thiazolylmethyl)-1H-benzimidazole trihydrobromide; mp. 208.3°-226.3° C. (72).

Workup

  1. temperaturerefluxed for 15 minutes
  2. customThe reaction mixture was evaporated
  3. customThe oily residue was crystallized from a mixture of ethanol and 2-propanone

Sources & evidence

ORD record
ord-c0a07562d5494be181c847b25e237e57
Source dataset
uspto-grants-1989_06
Patent number
US04839374

Reaction notes

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